Importance of Blood Brain Barriers in CNS

The term blood-brainbarrier has a significant importance. It describes the morphological, molecularand physiological functioning that controls efflux and influx of molecules inbetween the blood streams and brain.  This mechanisms results a stableinternal environment of brain with characteristics. The major role ofblood-brain barrier (BBB) is to protect the neural tissue from variations whenoccurred in blood composition and toxins.    The control oversubstance which enters or leaves the brain regions is done by endothelial cellsthat form blood - brain barriers. In adult’s complex cellular systems withbasal membrane and number of pericytes, astrocytes are embedded.  There isa differentiation in endothelial cells of brain and endothelial cells ofdifferent organs in two ways:  Prevention of Para cellular movement ofmolecules and confirmation of no detectable Tran’s endothelial pathways thebasal and specific proteins present in membrane are involved in the developmentof blood brain barrier. Astrocyte foot processes contributes for brain swellingthat allow water intake. Movement of solutes into the brain is done by transportcarriers mainly for glucose and amino acids (essential). Efflux of smallermolecules and mainly non-essential amino acids from the region of brain toblood is caused by secondary transport systems. They control the entry of neurotransmitters to brain.
  • Maintenance of chemical components of neuronal environment
  • Protection from Relative Immune Privilege
  • Barrier function and Carrier function
  • Neuro Immune function
  • Agents that cause improved functions
  • Hydrogen bonding Property
  • Pathological states involving BBB breakdown
  • Formation of tight Barriers
  • Strategies for Drug delivery
  • Impulse generation

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